Peter O’Mahony captains Ireland for the Round 4 visit to London, with Hugo Keenan returning to the starting XV after recovering from injury.
The IRFU confirmed that Keenan joins Calvin Nash and James Lowe in the Ireland back three, with Bundee Aki and Robbie Henshaw continuing their midfield partnership.
Jack Crowley and Jamison Gibson-Park are retained as the half-back pairing.
In the pack, Andrew Porter, Dan Sheehan and Tadhg Furlong are in the front row, with Joe McCarthy and Tadhg Beirne named in the engine room. Captain O’Mahony is at blindside flanker, Josh van der Flier is at openside and Caelan Doris completes the starting XV at number eight.
The Ireland Coaching Team have selected a 6-2 split on the bench, as Ronan Kelleher, Cian Healy, Finlay Bealham, Iain Henderson, Ryan Baird and Jack Conan provide the reinforcements in the pack.
Backs Conor Murray and Ciaran Frawley complete Ireland’s Match Day 23 to face England.